What is Oxidative Stress

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Before and after oxidation (use the arrows on the image to move to left or right)

Scientists agree that ageing and age-associated diseases are the result of cellular deterioration due to destructive molecules called Reactive Oxygen Species (ROS) that are produced in cells as our bodies process the oxygen that we breathe and our cells produce energy from it.

With more and more ROS produced in our cells it is noteworthy that our internal defences are overwhelmed and the equilibrium inside our cells is broken in favour of ROS. That is what is called OXIDATIVE STRESS, the same process that causes RUST.

In a sense, AGEING is your body’s way of RUSTING from the inside out!

Oxidative stress caused by ROS plays an important role in ageing and age-associated degenerative diseases. With these constant attacks by free radicals, it’s easy to see how the body gets worn down. So, decreasing ROS is essential to guarantee a healthy ageing process.

How oxidative stress is produced?


In fact, there are millions of processes taking place in our bodies at this moment that can result in oxidation. When we age, our body has more and more problems to control this overrun process.

Why is it a problem?


There are over 200 chronic diseases in peer-reviewed scientific articles linked to oxidative stress. Some of health challenges associated oxidative stress include: cardiovascular disease, both male and female infertility syndromes, hearing loss, chronic inflammatory diseases (like bowel disease), cognitive impairment due to ageing brain, joint diseases associated with pain and inflammation, skin pathologies and more.

Indeed, genetic mutations and manipulations that confer resistance to oxidative stress also cause extended life-span as scientist have been discovered. Thus, interventions aimed at decreasing free radicals are essential to guarantee a healthy ageing process.


How to reduce Oxidative Stress


The first shield against oxidative is the superoxide dismutase (SOD) enzyme. Ubiquitous to all forms of life exposed to oxygen, protects living beings from oxidation for over 2 billion years.

SOD plays a critical role in preventing oxidative stress: it is the only antioxidant agent able to control the production of ROS and prevent cell oxidation.

Antioxidant enzyme vs classical antioxidant

Antioxidant enzyme (also called “primary antioxidants”) have high catalytic properties and are involved in the elimination of millions of free radicals. On the contrary, classical antioxidants (also called “secondary antioxidants”) quench only one free radical and are quickly exhausted with no possibility of renewal.

Did you know that...

Recent studies have stated that the activation of Nrf2 pathway is the clue to restore the balance between ROS and cellular defences because is the key switch/shift for maintaining the proper antioxidant status of the cell? It stimulates endogenous production of SOD, CAT and GPx. SOD is an active ingredient that reacts against ROS and remains active to react with other ROS, neutralizing up to 1 million free radicals.

So, wouldn’t it be far more efficient to treat the core cellular driver of all of these health challenges rather than using medicines to individually treat one by one?

In fact, there are actually a growing number of scientists & consumers who believe this and are switching to this approach! Become part of TetraSOD® Community and discover how to control and reduce oxidative stress in your daily life.


What is Superoxide dismutase

Superoxide dismutases (SOD) are considered key factors in cellular protection against superoxide, representing the first line of defense to prevent oxidative damage, being the most powerful antioxidant in the cell. SOD catalyzes the dismutation of superoxide anion to hydrogen peroxide (H2O2), which is further transformed to water (H2O) and molecular oxygen (O2) by the accessory enzymes glutathione peroxidase (GPx) and catalase (CAT).

Given the critical function of SOD, these enzymes can be found in all taxonomic groups of living organisms, from prokaryotes (archaea and bacteria) to lower and higher eukaryotes, differing in the number of different enzymes they possess. All known SOD are metalloenzymes, that is, they require a metal cofactor for the activity, with iron (Fe), zinc (Zn), nickel (Ni), copper (Cu) and manganese (Mn) being those normally bound to SOD.

TetraSOD® exhibits the highest SOD activity found currently in nature. Under the production technology developed by Fitoplancton Marino, figures higher than 30,000 IU/g of biomass can be measured. A detailed bioinformatic analysis of the available genetic information for the microalgae T. chuii has allowed the identification of three genes encoding for SOD, each one potentially corresponding to either Mn, Cu-Zn, or Ni isoforms. The combined action of these three enzymes contributes to the extremely high global SOD activity displayed by TetraSOD®

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